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18-07-2019  |  998x
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Coupling GCxGC with QTOF detection in MS/MS mode

Our application specialist Daniela Peroni has published a new application note

The Agilent 7250 QTOF detector delivers high-resolution MS data, tunable ionization energy and MS/MS capability. Accurate-mass spectra with classic ionization can therefore be complemented with soft ionization spectra as well as MS/MS data for identity confirmation of targets and structure elucidation of unknowns. This makes GC-QTOF valuable for challenging applications that demand confident identification in highly complex matrices (e.g. metabolomics, pesticides analysis).

Comprehensive two-dimensional gas chromatography (GCGC) is the chromatographic method of choice to unravel high sample complexity. Compared to classic GC, GCGC grants superior separation power and unmatched peak capacity by coupling two different separation mechanism in a single analysis. Co-elutions are avoided or minimized, granting easier identification and more reliable quantification.

Several examples are available for GCGC in combination with the QTOF used in scan mode as a HRMS-TOF detector. The elevated number of resolved peaks and the clean 2D spectra, in combination with formula generation based on accurate-mass data, allow more precise and informative profiling. However, up to now GCGC is hardly used in combination with the QTOF in MS/MS mode. In the full application note the feasibility of GCGC-QTOF-MS/MS is investigated.

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